RT Journal Article SR Electronic T1 Exposure to fibres and risk of pleural mesothelioma in the Norwegian Offshore Petroleum Workers cohort JF Occupational and Environmental Medicine JO Occup Environ Med FD BMJ Publishing Group Ltd SP 331 OP 338 DO 10.1136/oemed-2024-109424 VO 81 IS 7 A1 Berge, Leon Alexander Mclaren A1 Shala, Nita Kaupang A1 Barone-Adesi, Francesco A1 Hosgood, H Dean A1 Samuelsen, Sven Ove A1 Bråtveit, Magne A1 Kirkeleit, Jorunn A1 Silverman, Debra A1 Friesen, Melissa C A1 Babigumira, Ronnie A1 Grimsrud, Tom K A1 Veierød, Marit B A1 Stenehjem, Jo S YR 2024 UL http://oem.bmj.com/content/81/7/331.abstract AB Objectives Pleural mesothelioma is a rare respiratory cancer, mainly caused by inhalation of asbestos fibres. Other inorganic fibres are also suggested risk factors. We aimed to investigate the association between exposure to asbestos or refractory ceramic fibres (RCFs) and pleural mesothelioma among male Norwegian offshore petroleum workers.Methods Among 25 347 men in the Norwegian Offshore Petroleum Workers (NOPW) cohort (1965–1998), 43 pleural mesothelioma cases were identified through the Cancer Registry of Norway (1999–2022). A case–cohort study was conducted with 2095 randomly drawn non-cases from the cohort. Asbestos and RCF exposures were assessed with expert-made job-exposure matrices (JEMs). Weighted Cox regression was used to estimate HRs and 95% CIs, adjusted for age at baseline and pre-offshore employment with likely asbestos exposure.Results An increased risk of pleural mesothelioma was indicated for the highest versus lowest tertile of average intensity of asbestos (HR=1.21, 95% CI: 0.57 to 2.54). Pre-offshore asbestos exposure (vs no such exposure) was associated with increased risk of pleural mesothelioma (HR=2.06, 95% CI: 1.11 to 3.81). For offshore workers with no pre-offshore asbestos exposure, an increased risk of pleural mesothelioma was found for the highest tertile of average intensity of asbestos (HR=4.13, 95% CI: 0.93 to 18), versus the lowest tertile. No associations were found between RCF and pleural mesothelioma.Conclusions Associations between JEM-based offshore asbestos exposure and pleural mesothelioma were confirmed in the NOPW cohort. Pleural mesothelioma risk was also associated with asbestos exposure before work in the offshore petroleum industry.Data may be obtained from a third party and are not publicly available. The data are available as presented in the paper. According to Norwegian legislation, our approvals to use the data for the current study do not allow us to distribute or make the data directly available to other parties.